Suchen und Finden
Challenging Cases in Allergic and Immunologic Diseases of the Skin
von: Massoud Mahmoudi
Springer-Verlag, 2010
ISBN: 9781607612964 , 347 Seiten
Format: PDF
Kopierschutz: Wasserzeichen
Preis: 106,99 EUR
Challenging Cases inAllergic and ImmunologicDiseases of the Skin
3
Preface
7
Contents
9
Contributors
11
Part I Urticaria and Angioedema
15
Chapter 1: Urticaria
16
Case 1
16
With the Presented Data What Is Your Working Diagnosis?
18
Differential Diagnosis
18
Workup
18
What Is Your Diagnosis and Why?
19
Management and Follow-Up
19
Questions
19
Case 2
20
With the Presented Data What Is Your Working Diagnosis
22
Differential Diagnosis
23
Workup
23
What Is Your Diagnosis and Why?
24
Management and Follow-Up
24
Questions
24
Discussion
25
Definition
25
Brief History
25
Prevalence of Urticaria
26
Pathophysiology
26
Clinical Manifestations
27
Ordinary Urticaria
27
Physical Urticaria
28
Urticaria due to Mechanical Stimuli
28
Dermographism
28
Immediate Pressure Urticaria
28
Delayed Pressure Urticaria
29
Vibratory Angioedema
29
Temperature Change Urticaria
29
Heat Urticaria
29
Cold Urticaria
29
Exercise-Induced Anaphylaxis
30
Solar Urticaria
30
Aquagenic Urticaria
30
Contact Urticaria
30
Angioedema Without Wheals
31
Urticarial Vasculitis
31
Urticarial Syndromes
31
Muckle–Wells Syndrome
31
Schnitzler Syndrome
32
Autoimmune Progesterone Dermatitis
32
Diagnostic Procedures
32
History-Taking
32
Laboratory Test
33
Treatment
33
Conclusion
35
References
35
Chapter 2: Cold Urticaria
37
Case 1
37
With the Presented Data, What Is Your Working Diagnosis?
38
Differential Diagnosis
38
Work-Up
39
What Is Your Diagnosis and Why?
39
Follow-up
39
Case 2
40
With the Presented Data, What Is Your Working Diagnosis?
42
Differential Diagnosis
42
Work-Up
42
What Is Your Diagnosis and Why?
43
Discussion
43
Definition
43
Differential Diagnosis
44
Pathophysiology
46
Presentation
46
Work-Up
46
Treatment
52
Questions
54
References
55
Chapter 3: Contact Urticaria Syndrome
57
Introduction
57
Case 1
57
Chief Complaint
57
History of Present Illness
58
Past Medical History
58
Physical Examination
58
Differential Diagnosis
58
Impression and Follow-Up
58
Case 2
59
Chief Complaint
59
History of Present Illness
59
Family History
59
Review of Systems
59
Social History
59
Physical Examination
60
Differential Diagnosis
60
Impression and Follow-Up
60
Discussion
60
History
60
Prevalence
61
Pathophysiology
63
Clinical Presentation, Testing, and Diagnosis
65
Treatment
67
Questions
68
References
70
Chapter 4: Idiopathic Angioedema
71
Case 1
71
With the Presented Data, What is Your Working Diagnosis?
74
Workup
74
What is Your Diagnosis and Why?
75
Case 2
76
With Presented Data, What Is Your Working Diagnosis?
77
Workup
77
What Is Your Diagnosis and Why?
78
Discussion
79
Evaluation
80
Workup
80
Management
81
Questions
82
References
83
Chapter 5: Hereditary Angioedema
85
Case 1
85
With the Above Data, What Is Your Working Diagnosis?
87
Work-Up
88
What Is Your Diagnosis and Why?
89
Case 2
89
With These Presented Data What Is Your Working Diagnosis?
90
Work-Up
91
What Is Your Diagnosis and Why?
92
Discussion
92
Pathophysiology
95
Work-Up
95
Management and Treatment
96
Questions
98
References
100
Part IISkin Manifestation of Drug Allergy
101
Chapter 6: Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis
102
Case 1
102
Data
103
Discussion
105
Case 2
108
Data
109
Discussion
110
Questions
111
Case 2
115
Case 3
117
References
119
Chapter 7: Serum Sickness and Serum Sickness-Like Reaction
121
Case 1
121
Diagnostic Testing (Results from 2005)
123
With the Presented Data, What Is Your Working Diagnosis?
123
Impression
123
Plan
123
Differential Diagnoses
123
Workup
124
What Is Your Diagnosis and Why?
124
Case 2
125
Data
126
With the Presented Data, What Is Your Working Diagnosis?
126
Workup
127
What Is Your Diagnosis and Why?
127
Discussion
129
Questions
131
References
133
Part IIIAllergic Contact Dermatitis
134
Chapter 8: Preservatives
135
Case 1
135
With the Presented Data, What Is Your Working Diagnosis?
136
Differential Diagnosis
136
Workup
136
What Is Your Diagnosis and Why?
136
Management and Follow-Up
136
Case 2
137
With the Presented Data, What Is Your Working Diagnosis?
137
Differential Diagnosis
137
Workup
137
What Is Your Diagnosis and Why?
137
Management and Follow-Up
138
Discussion
138
Definition
138
Brief History
138
Prevalence of AC.D and Types of Preservatives
139
Formaldehyde
139
Quaternium-15
141
Imidazolidinyl Urea
142
2,5-Diazolidinyl Urea
142
Methylchloroisothiazolinone/Methylisothiazolinone
143
Methyldibromoglutaronitrile (MDBNG)/phenoxyethanol
143
Parabens
143
Pathophysiology
144
Diagnostic Procedures
144
Conclusion
145
Questions
145
References
147
Chapter 9: Allergic Contact Dermatitis: Rubber Allergies
148
Case 1
148
History of Present Illness
148
Physical examination
149
Differential diagnosis
149
Working diagnosis
149
Impression and follow-up
149
Case 2
149
History of present illness
149
Physical examination
150
Differential
150
Working diagnosis
150
Impression and follow-up
150
Discussion
150
Historical Background
150
Prevalence of Rubber-Based Contact Dermatitis
151
Immunology and Pathophysiology of Rubber Allergic Contact Dermatitis
152
Clinical Manifestations of Rubber Allergic Contact Dermatitis
154
Diagnosis and Treatment
156
Questions
157
References
158
Chapter 10: Jewelry: Nickel and Metal-Based Allergic Contact Dermatitis
160
Case 1
160
History of Present Illness
160
Physical Examination
161
Differential Diagnosis
161
Working Diagnosis
161
Impression and Follow-Up
161
Case 2
161
History of Present Illness
161
Physical Examination
162
Differential Diagnosis
162
Working Diagnosis
162
Impression and Follow-Up
162
Discussion
163
Historical Background
163
Prevalence of Metal-Based Contact Dermatitis
163
Impact of Patient Factors on Contact Allergy with Nickel and other Metals
164
Immunology and Pathophysiology of Metal ACD
165
Allergenicity of Gold, Cobalt, and Palladium
167
Gold
167
Cobalt
167
Palladium
168
Clinical Presentation of Metal Allergy
168
Diagnosis and Treatment
169
Questions
172
References
174
Chapter 11: Allergic Contact Dermatitis to Fragrances
176
Case 1
176
With the Presented Data, What Is Your Working Diagnosis?
177
Differential Diagnosis
177
Work-Up
177
What Is Your Diagnosis and Why?
177
Management and Follow-Up
177
Case 2
178
With the Presented Data, What Is Your Working Diagnosis?
178
Differential Diagnosis
178
Work-Up
178
What Is Your Diagnosis and Why?
178
Management and Follow-Up
179
Case 3
179
With the Presented Data, What Is Your Working Diagnosis?
179
Differential Diagnosis
179
Work-Up
179
What Is Your Diagnosis and Why?
180
Management and Follow-Up
180
Discussion
180
Definition
180
History and Prevalence
180
Pathophysiology
181
Clinical Presentation, Testing, and Diagnosis
181
Conclusion
184
Questions
184
References
187
Part IVOther Allergies Affecting Skinand Mucous Membranes
188
Chapter 12: Atopic Dermatitis
189
Case 1
189
With the Presented Data, What is Your Working Diagnosis?
191
Workup
192
Data
192
What is Your Diagnosis and Why?
192
Management and Follow-Up
192
Case 2
193
With the Presented Data, What is Your Working Diagnosis?
193
Workup
194
Data
195
What is Your Diagnosis and Why?
196
Management and Follow-Up
196
Discussion
198
Prevalence
198
Typical Presentation
198
Histology
199
Genetics
199
Immunology
200
Diagnosis
201
Treatment
201
Questions
204
References
206
Chapter 13: Allergic Reactions Affecting Mucosal Surfaces
207
Case 1
207
Laboratory Data
208
Initial Impression
208
Differential Diagnosis
208
Clinical Evaluation
209
Identification and Confirmation of Relevant Seminal Plasma Sensitizing Proteins
209
Gel Filtration Chromatography
209
IgE-Specific Enzyme-Linked Immunosorbent Assay and ELISA Inhibition
210
Sodium dodecyl sulfate – polyacrylamide gel electrophoresis and Western Immunoblotting of SP
211
With the Presented Data, What Is Your Diagnosis?
211
Discussion
211
Questions
213
Case 2
214
Laboratory Data
214
Initial Impression
214
Differential Diagnosis
215
Clinical Evaluation
215
IgE Measurement and C. albicans Immunocap Testing
215
With the Presented Data, What Is Your Diagnosis?
215
Discussion
215
Questions
218
References
219
Part VImmunologic Diseases of the Skin
221
Chapter 14: Vasculitis
222
Case 1
222
Data
223
Imaging Studies
223
Discussion
223
Case 2
228
Data
228
Imaging Studies
229
Discussion
229
Questions
231
Case 1
231
Case 2
233
Case 3
236
Answers
239
Questions
239
References
239
Chapter 15: Cutaneous Mastocytosis
241
Case 1
241
With the Presented Data, What is Your Working Diagnosis?
243
Differential Diagnosis
243
Workup
243
What is Your Diagnosis and Why?
244
Case 2
244
With the Presented Data, What is Your Working Diagnosis?
245
Differential Diagnosis
245
Workup
245
What is Your Diagnosis and Why?
246
Discussion
247
Questions
252
References
254
Chapter 16: Cutaneous Lupus
255
Case 1
255
Data
257
With the Presented Data, What Is Your Working Diagnosis?
257
Workup
258
Skin Biopsy
258
What is Your Diagnosis and Why?
258
Discussion
258
Questions
261
Case 2
262
With the Presented Data, What Is Your Working Diagnosis?
264
Workup
264
What is Your Diagnosis and Why?
264
Discussion
266
Questions
268
References
269
Chapter 17: Psoriasis
270
Clinical Presentation
270
Case 1
270
What Is Your Working Diagnosis?
271
Differential Diagnosis
271
Workup
271
What Is Your Diagnosis and Why?
271
Management and Treatment
272
Case 2
272
What Is Your Working Diagnosis?
272
Differential Diagnosis
273
Workup
273
What Is Your Diagnosis and Why?
273
Management and Follow-Up
273
Discussion
274
Background
274
Pathophysiology
274
Brief History
274
Molecular Pathogenesis
274
Genetics
275
Clinical Manifestations
276
Plaque Psoriasis
276
Erythrodermic Psoriasis
277
Guttate Psoriasis
277
Pustular Psoriasis
278
Inverse Psoriasis
279
Psoriatic Arthritis
279
Other Clinical Findings
279
Psoriasis and Other Comorbidities
279
Differential Diagnosis
280
Management
281
History
281
Diagnostic Procedures
281
Treatment
283
Conclusion
284
Questions
285
References
287
Chapter 18: Scleroderma
289
Case 1
289
What Is Your Initial Impression About This Patient?
291
Differential Diagnosis
292
With the Presented Data, What Is Your Diagnosis and Why?
294
Discussion
294
Questions
296
Case 2
297
With the Presented Data, What Is Your Working Diagnosis?
298
Differential Diagnosis
299
Workup
299
What Is Your Diagnosis and Why?
300
Discussion
300
Questions
302
References
303
Chapter 19: Autoimmune Blistering Diseases of the Skin and Mucous Membranes
305
Case 1
305
What Is the Differential Diagnosis?
306
What Is the Appropriate Workup in This Patient?
307
Test Results
308
Based on the Histology and Immunofluorescence Findings, What Is the Best Diagnosis in This Patient?
308
What Is the Appropriate Treatment for This Patient?
308
What Is the Significance of Lichenoid Dermatitisin a Patient With Pemphigus?
309
With the Consideration of Paraneoplastic Pemphigus, What Should the Next Step Be in the Workup of the Patient?
310
Discussion
312
Case 2
313
What Is the Differential Diagnosis?
314
What Is the Next Step in the Workup of the Patient?
315
With These Clinical and Pathologic Findings, What Is Your Best Diagnosis?
316
Is There Any Test That Can Be Performed to Differentiate Between MMP and EBA?
318
With MMP as the Most Likely Diagnosis, How Shouldthe Management of This Patient Proceed?
318
Given That Conservative Treatment Measures Have Failed, What Is the Next Step?
319
With These New Ocular Findings, How Does This Change Therapy?
319
Discussion
320
Questions
321
References
323
Chapter 20: Alopecia Areata*
324
Case 1
324
Case Presentation
324
With the Presented Data What Is Your Working Diagnosis?
325
Differential Diagnosis
325
Work-Up
326
What Is Your Diagnosis and Why?
326
Case 2
327
Case Presentation
327
Data
328
With the Presented Data What Is Your Working Diagnosis?
328
Differential Diagnosis
328
Work-Up
329
What Is Your Diagnosis and Why?
329
Discussion
330
Definition/Epidemiology
330
Presentation
330
Pathophysiology/Genetics
332
Work-Up
333
Management/Prognosis
333
Questions
337
References
338
Index
340
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