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Front Cover
1
Handbook of Stress and the Brain: The Neurobiology of Stress
4
Copyright Page
5
Contents
16
List of Contributors
6
Preface
12
A Memorial for David de Wied (1925–2004)
14
Section 1: Concepts of Stress
20
Chapter 1.1. Stress: an historical perspective
22
Chapter 1.2. The neuropsychology of stress
44
Chapter 1.3. An introduction to the HPA axis
62
Chapter 1.4. Hormones of the pituitary
86
Chapter 1.5. Molecular biology of the HPA axis
98
Chapter 1.6. The hypothalamic–pituitary–adrenal axis as a dynamically organized system: lessons from exercising mice
114
Section 2: Hypothalamic Hormones Involved in Stress Responsivity
132
Chapter 2.1. Novel CRF family peptides and their receptors: an evolutionary analysis
134
Chapter 2.2. Molecular regulation of the CRF system
152
Chapter 2.3. Behavioral consequences of altered corticotropin-releasing factor activation in brain: a functionalist view of affective neuroscience
174
Chapter 2.4. The roles of urocortins 1, 2, and 3 in the brain
198
Chapter 2.5. Vasopressin and oxytocin
224
Chapter 2.6. The role of vasopressin in behaviors associated with aversive stimuli
250
Section 3: Stress and the HPA Axis
282
Chapter 3.1. Corticosteroid receptors and HPA-axis regulation
284
Chapter 3.2. Glucocorticoid effects on gene expression
314
Chapter 3.3. The role of 11ß-hydroxysteroid dehydrogenases in the regulation of corticosteroid activity in the brain
332
Chapter 3.4. Corticosteroids and the blood-brain barrier
348
Chapter 3.5. Glucocorticoids and motivated behaviour
360
Chapter 3.6. Effects of glucocorticoids on emotion and cognitive processes in animals
378
Chapter 3.7. Glucocorticoids: effects on human cognition
406
Section 4: Neurotransmitter Systems Involved in Stress Responsivity
422
Chapter 4.1. Neurocircuit regulation of the hypothalamo–pituitary–adrenocortical stress response – an overview
424
Chapter 4.2. Sympatho-adrenal activity and hypothalamic–pituitary–adrenal axis regulation
438
Chapter 4.3. The locus coeruleus–noradrenergic system and stress: modulation of arousal state and state-dependent behavioral processes
456
Chapter 4.4. Functional interactions between stress neuromediators and the locus coeruleus–norepinephrine system
484
Chapter 4.5. Regional specialisation in the central noradrenergic response to unconditioned and conditioned environmental stimuli
506
Chapter 4.6. Stress, corticotropin-releasing factor and serotonergic neurotransmission
522
Chapter 4.7. Modulation of glutamatergic and GABAergic neurotransmission by corticosteroid hormones and stress
544
Chapter 4.8. Neuroactive steroids
564
Chapter 4.9. Endogenous opioids, stress, and psychopathology
580
Chapter 4.10. Acetylcholinesterase as a window onto stress responses
604
Chapter 4.11. Pathways and transmitter interactions mediating an integrated stress response
628
Section 5: Neuroplasticity and Stress
660
Chapter 5.1. The intracellular signaling cascade and stress
662
Chapter 5.2. The role of neurotrophic factors in the stress response
684
Chapter 5.3. Transcription factors as modulators of stress responsivity
698
Chapter 5.4. Experience, structural plasticity and neurogenesis
718
Chapter 5.5. Adult neurogenesis in rodents and primates: functional implications
730
Chapter 5.6. Cellular and molecular analysis of stress-induced neurodegeneration – methodological considerations
748
Chapter 5.7. Enhancing resilience to stress: the role of signaling cascades
770
Section 6: The Stressed Brain
792
Chapter 6.1. Psychological and physiological stressors
794
Chapter 6.2. Involvement of the amygdala in the neuroendocrine and behavioral consequences of stress
812
Chapter 6.3. Role of prefrontal cortex in stress responsivity
826
Subject Index
838
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