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Contents
6
Authors
11
Abbreviations
14
Preface
18
Part I Diagnosis of Gastrointestinal Disorders
20
1 Diagnostic Tools
22
1.1 Clinical History
22
1.1.1 Introduction
22
1.1.2 History of specific gastrointestinal signs
22
1.1.3 Dietary history
27
1.2 Physical Examination
28
1.2.1 Introduction
28
1.2.2 General physical examination
29
1.2.3 Examination of the gastrointestinal tract
32
1.3 Diagnostic Imaging
35
1.3.1 Introduction
35
1.3.2 Oropharynx
36
1.3.3 Esophagus
41
1.3.4 Stomach
44
1.3.5 Small intestine
47
1.3.6 Large intestine
55
1.3.7 Liver and biliary tract
57
1.3.8 Pancreas
63
1.4 Laboratory Tests
67
1.4.1 Laboratory assessment of gastric disease
67
1.4.2 Laboratory tests for the diagnosis of intestinal disorders
69
1.4.3 Laboratory tests for the diagnosis of liver disease
75
1.4.4 Laboratory tests for the diagnosis of exocrine pancreatic disorders
83
1.4.5 Molecular-genetics-based laboratory tests
86
1.5 Endoscopy
91
1.5.1 Introduction
91
1.5.2 Indications
91
1.5.3 Basic principles of endoscopy
91
1.5.4 Esophagogastroduodenoscopy
92
1.5.5 Colonoileoscopy
94
1.5.6 Proctoscopy
95
1.5.7 Diagnostic procedures
95
1.5.8 Appearance of the upper gastrointestinal tract
99
1.5.9 Interventional procedures
104
1.6 Diagnostic Laparoscopy
108
1.6.1 Introduction
108
1.6.2 Indications
108
1.6.3 Laparoscopic equipment and technique
109
1.6.4 Biopsy techniques
110
1.6.5 Ancillary procedures
114
1.7 Cytology
116
1.7.1 Introduction
116
1.7.2 Technique
116
1.7.3 Liver
116
1.7.4 Pancreas
120
1.7.5 Stomach and intestines
121
1.8 Histopathology
123
1.8.1 Introduction
123
1.8.2 Types of gastrointestinal biopsies
123
1.8.3 Advantages and disadvantages
124
1.8.5 Interpretation and misinterpretation of GI tract biopsies
125
1.9 Assessment of Gastrointestinal Motility
127
1.9.1 Disorders of gastrointestinal motility
127
1.9.2 Methods for assessing gastrointestinal motility
128
2 Clinical Evaluation of Dogs and Cats with Specific Clinical Signs
134
2.1 Clinical Evaluation of Patients with Acute Signs of Gastrointestinal Disease
134
2.1.1 Introduction
134
2.1.2 Diagnostic evaluation of vomiting
134
2.1.3 Diagnostic evaluation of acute diarrhea
136
2.2 Clinical Evaluation of Patients with Chronic Vomiting
139
2.2.1 Introduction
139
2.2.2 Initial evaluation
140
2.2.3 Diagnostic approach
142
2.2.4 Secondary gastrointestinal
143
2.2.5 Primary gastrointestinal disease
144
2.3 Clinical Evaluation of Patients with Chronic Diarrhea
146
2.3.1 Introduction
146
2.3.2 General workup
146
2.3.3 Division of patients according to the findings on initial evaluation
147
2.4 Clinical Evaluation of Patients with Chronic Weight Loss
152
2.4.1 Introduction
152
2.4.2 Pathophysiology
153
2.4.3 Etiology
153
2.4.4 Diagnosis
154
Part II Diseases of the Gastrointestinal Tract
158
3 Esophagus
159
3.1 Anatomy
159
3.2 Physiology
160
3.3 Diseases of the Esophagus
160
3.3.1 Cricopharyngeal achalasia
160
3.3.2 Esophagitis
161
3.3.3 Gastroesophageal reflux
162
3.3.4 Esophageal foreign bodies
162
3.3.5 Esophageal strictures
164
3.3.6 Esophageal diverticula
165
3.3.7 Airway-esophageal fistula
166
3.3.8 Megaesophagus
166
3.3.9 Hiatal hernia
167
3.3.10 Gastroesophageal intussusception
168
3.3.11 Vascular ring anomalies
168
3.3.12 Neoplastic conditions of the esophagus
171
4 Stomach
175
4.1 Introduction
175
4.2 Anatomy
175
4.3 Gastric physiology
175
4.3.1 Gastric glands
175
4.3.2 Gastric secretion
176
4.3.3 The gastric mucosal barrier
178
4.4 Diseases of the Stomach
179
4.4.1 Gastritis
179
4.4.2 Gastric dilation-volvulus
189
4.4.3 Motility disorders
191
4.4.4 Neoplastic conditions of the stomach
196
5 Small Intestine
201
5.1 Anatomy
201
5.1.1 Introduction
201
5.1.2 Gross anatomy of the intestinal tract
201
5.2 Intestinal Physiology
203
5.2.1 Introduction
203
5.2.2 Secretion, digestion, and villus
203
5.2.3 Regulation of secretion, absorption, and motility: gastrointestinal hormones
204
5.2.4 Gut-associated lymphoid tissue and the immune system
205
5.2.5 Intestinal bacteria
206
5.3 Small Intestinal Disease
207
5.3.1 Introduction
207
5.3.2 Infectious causes of small intestinal disease
207
5.3.3 Dietary indiscretion (garbage can intoxication)
218
5.3.4 Intestinal obstruction – intestinal foreign bodies, intussusception and intestinal torsion,
218
5.3.5 Hemorrhagic gastroenteritis (HGE)
219
5.3.6 Short bowel syndrome
219
5.3.7 Motility disorders
219
5.3.8 Alterations in the small intestinal microflora (Small intestinal bacterial overgrowth)
222
5.3.9 Protein-losing enteropathies
227
5.3.10 Neoplastic diseases of the small intestines
231
6 Large Intestine
237
6.1 Introduction
237
6.2 Anatomy
237
6.3 Physiology
238
6.3.1 Motility
238
6.3.2 Water and electrolyte transport
239
6.3.3 Mucus secretion
240
6.3.4 Colonic microflora
240
6.3.5 Immune function
240
6.4 Diseases of the Large Intestine
241
6.4.1 Whipworms
241
6.4.2 Colitis
243
6.4.3 Irritable bowel syndrome
246
6.4.4 Fiber-responsive large bowel diarrhea
247
6.4.5 Feline megacolon
250
6.4.6 Neoplastic diseases of the large intestines
256
7 Liver
261
7.1 Anatomy
261
7.1.1 Biliary system
261
7.1.2 Blood supply
262
7.1.3 Microanatomy
263
7.2 Physiology
264
7.3 Diagnostic approach to patients function of many extrahepatic tissues, so that hepatic disease
265
7.3.1 Prevalence of liver disease
266
7.3.2 Symptoms associated with liver diseases
266
7.3.3 Physical examination
267
7.3.4 Diagnostic tests for liver disease
267
7.3.5 Liver biopsy
268
7.4 Complications of liver disease
270
7.4.1 Ascites
270
7.4.2 Jaundice
270
7.4.3 Hepatic encephalopathy
271
7.4.4 Coagulopathies
274
7.4.5 Polyuria and polydipsia
275
7.5 Liver diseases of the dog
275
7.5.1 Parenchymal liver diseases of the dog
275
7.5.2 Parenchymal changes of the liver during systemic disease
282
7.5.3 Vascular diseases of the liver
283
7.5.4 Diseases of the biliary tract
289
7.5.5 Neoplastic conditions of the liver
290
7.6 Liver diseases in the cat
292
7.6.1 Parenchymal liver diseases in cats
292
7.6.2 Vascular liver diseases in cats
295
7.6.3 Diseases of the biliary system in cats
295
7.6.4 Neoplasia
298
8 Exocrine Pancreas
303
8.1 Anatomy
303
8.2 Physiology
304
8.3 Diseases of the exocrine pancreas
305
8.3.1 Pancreatitis
305
8.3.2 Exocrine pancreatic insufficiency
314
8.3.3 Exocrine pancreatic neoplasia
319
8.3.4 Rare diseases of the exocrine pancreas
321
9 Diseases that affect more than one Organ of the Gastrointestinal Tract
327
9.1 Adverse Reactions to Food – Allergy versus Intolerance
327
9.1.1 Introduction
327
9.1.2 Terminology
327
9.1.3 Etiopathogenesis of food allergy
327
9.1.4 Food allergies
328
9.2 Inflammatory Bowel Disease
332
9.2.1 Introduction
332
9.2.2 Common principles of IBD
333
9.2.3 Lymphoplasmacytic enteritis (LPE)
344
9.2.4 Lymphoplasmacytic colitis (LPC)
344
9.2.5 Basenji enteropathy
345
9.2.6 Familial PLE and PLN in Softcoated Wheaten Terriers
345
9.2.7 Eosinophilic enteritis (EE)
346
9.2.8 Granulomatous enteritis
346
9.2.9 Histiocytic ulcerative colitis (HUC)
347
9.2.10 Proliferative enteritis
347
9.3 Gastrointestinal Lymphoma
349
9.3.1 Feline gastrointestinal lymphoma
349
9.3.2 Canine gastrointestinal lymphoma
355
9.4 Neuroendocrine Tumors of the Gastrointestinal Tract
357
9.4.1 Introduction
357
9.4.2 Insulinoma
357
9.4.3 Gastrinoma
364
9.4.4 Glucagonoma
367
9.4.5 Pancreatic polypeptidoma
369
9.4.6 Carcinoids
369
9.4.7 Other neuroendocrine tumors of the gastrointestinal tract
370
Subject Index
372
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